Huginn is a python twitter application. It started because no existing client supported the Lists API, but has grown to be a general-purpose Twitter client.
Copy the supplied huginn.conf file to ~/.huginn.conf, and edit it to suit your preferences. At a minimum, you need to change the [account] section to contain a valid twitter username and password. You can have multiple [account] sections, but they must be uniquely named, and the section name must start with 'account'.
Just run ./huginn.py, and start playing around. Right now, it is best to run this file in-place; it expects twitterwidgets.py and default.glade to be in the same directory.